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The University of Chicago Medical Center, also known under the umbrella of University of Chicago Medicine, is an American academic medical center in Hyde Park on the of South Side of Chicago, established in 1927. Affiliated with and operated by the University of Chicago, it serves as the teaching hospital for students of the institution's Pritzker School of Medicine.

Once known as the University of Chicago Hospitals, it was reorganized as the University of Chicago Medical Center in 2006, which it is still legally named. However, it operates under the umbrella of University of Chicago Medicine.

In 2007, the University of Chicago Medical Center was again ranked among the best in the country by U.S. News & World Report. The 2010 rankings by U.S. News & World Report included the following 11 adult medical specialties: digestive disorders (6), cancer (15), endocrinology (18), kidney disease (21), respiratory disorders (21), heart (27), urology (28), geriatrics (29), gynecology (34), neurology and neurosurgery (36) and, ear, nose, and throat (38). Until 2012, it was the only hospital in Illinois ever to be included on the magazine's "Honor Roll" of the best hospitals in the United States, and has made this coveted list 10 times.