Prince Lerotholi Seeiso (born 18 April 2007) is a member of the Royal Family of Lesotho.
Prince Lerotholi Mohato Bereng Seeiso was born in Maseru and is the third child and only son of King Letsie III of Lesotho and Queen 'Masenate Mohato Seeiso. He has two older sisters, the Princesses Senate and Maseeiso. Prince Lerotholi was named after Lerotholi, the Paramount Chief of Basuto from 1891 to 1905.
Prince Lerotholi was baptized as David at the Roman Catholic St. Louis Church at Matsieng on 2 June 2007 by the head of the Roman Catholic Church in Lesotho, Archbishop Bernard Mohlalisi. The Principal Chief of Likhoele, Lerotholi Seeiso, is his godfather.